Channel 12 and 47 do not require a large antenna. KXTV CH-10 is going to require some effort though. Is there a reason KGO CH-7 won't be an acceptable alternative?
If you absolutely must have KXTV CH-10, I would recommend a two antenna system. The ANT-751 John has suggested is an excellent choice, another would be an Antennacraft HBU-22. (One of those would be your primary antenna system)
A dedicated high band VHF antenna such as the Y10713 would be my suggestion if you are going to explicitly attempt to receive KXTV. Click on the call sign in your TVF report and you will see the cross section of terrain you will be trying to overcome. I can't offer a guaranty of success even if you gang two Y10713 antennas.
http://forum.tvfool.com/showthread.php?t=1024 Amplifiers will be prone to overload from the other strong signals. A commercial quality single channel filter would likely be needed ahead of any amplifier.
http://www.tinlee.com/bandpass_filters.php?active=3#CF7