No Amplifier will have the ability to filter out noise or interference. The job of an amplifier is to overcome loss in cable, splitters and possibly the noise generated inside a tuner. Amplifiers can not and will not improve the performance of an antenna. An amplifier can only 'push' a stronger copy of what arrives at it's input down the line. Amplifiers can not 'pull' signals from the antenna or the air.
With some determined and persistent experimentation, you may be able to find a location and aim point that offers maximum signal from a desired station while at the same time, minimal reception of an interfering signal. Some folks have gone so far as to experiment with stacked/ganged antenna arrays.
http://forum.tvfool.com/showthread.php?t=1024
A Winegard AP-2880 can handle a fairly strong input in the UHF band... It's easier to overload in the VHF band. If you already own one, try it. As of the moment, the RCA TVPRAMP1R is still available and has demonstrated a good deal of resistance to overloading. I'm looking forward to testing the new preamp that Antennas Direct has been developing.